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Input Sequences

Protein:

RNA:

Interaction probabilities
Prediction using RF classifier		0
Prediction using SVM classifier		0

What do these probabilities mean?
 Interaction probabilities generated by RPISeq range from 0 to 1. In performance evaluation experiments, predictions with probabilities > 0.5 were considered “positive,” i.e., indicating that the corresponding RNA and protein are likely to interact. Using this threshold, accuracies of the classifiers ranged from 87 - 90% in cross-validation evaluation experiments on benchmark datasets. When classifiers were tested on independent (blind) datasets of RPIs, accuracies of the classifiers ranged from 57 – 99%.

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